phenytoin will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to the lower in fentanyl plasma concentrations, insufficient efficacy or, perhaps, improvement of the withdrawal syndrome within a affected ind
If coadministration of CYP3A4 inhibitors with fentanyl is critical, keep track of patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose changes until stable drug effects are accomplished.For oral drugs where reductions in bioavailability could cause clinically sizeable effects on its safety or efficacy, s
Frequently evaluate patients, especially when initiating and titrating dose and when given concomitantly with other drugs that depress respiration; alternatively, consider usage of non-opioid analgesics in these patientsObserve Intently (two)primidone will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabo
bosentan will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to some lower in fentanyl plasma concentrations, not enough efficacy or, possibly, enhancement of the withdrawal syndrome inside a affected pers
Hoehe M, 1988. Influence of your menstrual cycle on neuroendocrine and behavioral responses to an opiate agonist in humans: preliminary results. PsychoneuroendocrinologyIf coadministration of CYP3A4 inhibitors with fentanyl is important, observe patients for respiratory depression and sedation at Repeated intervals and consider fentanyl dose adjust